## Drug holidays and losing resistance with replicator dynamics

September 2, 2016 2 Comments

A couple of weeks ago, before we all left Tampa, Pranav Warman, David Basanta and I frantically worked on refinements of our model of prostate cancer in the bone. One of the things that David and Pranav hoped to see from the model was conditions under which adaptive therapy (or just treatment interrupted with non-treatment holidays) performs better than solid blocks of treatment. As we struggled to find parameters that might achieve this result, my frustration drove me to embrace the advice of George Pólya: “If you can’t solve a problem, then there is an easier problem you can solve: find it.”

In this case, I opted to remove all mentions of the bone and cancer. Instead, I asked a simpler but more abstract question: what qualitative features must a minimal model of the evolution of resistance have in order for drug holidays to be superior to a single treatment block? In this post, I want to set up this question precisely, show why drug holidays are difficult in evolutionary models, and propose a feature that makes drug holidays viable. If you find this topic exciting then you should consider registering for the 6th annual Integrated Mathematical Oncology workshop at the Moffitt Cancer Center.^{[1]} This year’s theme is drug resistance.

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## Social algorithms and the Weapons of Math Destruction

September 14, 2016 by Artem Kaznatcheev Leave a comment

Cathy O’Neil holding her new book:

Weapons of Math Destructionat a Barnes & Noble in New York city.alreadyproblems to deal with. Problems that don’t involve super intelligent tin-men, killer robots, nor sentient machine overlords. Focusing on distant speculation obscures the fact that algorithms — and not necessarily very intelligent ones — already reign over our lives. And for many this reign is far from benevolent.I owe much of my knowledge about the (negative) effects of algorithms on society to the writings of Cathy O’Neil. I highly recommend her blog

mathbabe.org. A couple of months ago, she shared the proofs of her bookWeapons of Math Destructionwith me, and given that the book came out last week, I wanted to share some of my impressions. In this post, I want to summarize what makes a social algorithm into a weapon of math destruction, and share the example of predictive policing.Read more of this post

Filed under Books, Commentary, Reviews Tagged with ethics and morality