## Simplifying models of stem-cell dynamics in chronic myeloid leukemia

December 17, 2013 4 Comments

If I had to identify one then my main allergy would be bloated models. Although I am happy to play with complicated *insilications*, if we are looking at *heuristics* where the exact physical basis of the model is not established then I prefer to build the simpleast possible model that is capable of producing the sort of results we need. In particular, I am often skeptical of agent based models because they are simple to build, but it is also deceptively easy to have the results depend on an arbitrary data-independent modeling decision — the curse of computing. Therefore, as soon as I saw the agent-based models for the effect of imatinib on stem-cells in chronic myeloid leukemia (Roeder et al., 2002; 2006; Horn et al., 2013 — the basic model is pictured above), I was overcome with the urge to replace it by a simpler system of differential equations.

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