Microenvironmental effects in prostate cancer dynamics

Light_blue_ribbonI am currently visiting David Basanta and Jacob G. Scott at the Moffitt Cancer Center in Tampa, FL. I primarily study evolutionary game theory for the sake of evolutionary game theory. Sometimes I am curious about how it shapes our understanding of classic game theory, and how it broadly connects to other fields. Occasionally, I wander into pondering on economic or human questions, or at least sociobiology. However, the biggest application of EGT for most people is in biology, originally in the study of fisheries of sex-allocation and now even in medical fields like cancer research. Although I have briefly alluded to work on cancer before, it took the personal encouragement of David and Jacob for me to look at the field carefully. Naturally, I started with their paper. Half a year ago, I started drafting this post — my first on cancer — but it got lost in the perpetual “I’ll finish it up tomorrow” pile.

With only thirty minutes to spare, ‘tomorrow’ is finally today.

Over the last two days, David and I locked ourselves in his apartment and then office in the Integrated Mathematical Oncology Department. We discussed his papers on metastasis, the Warburg effect, and tumor-stroma interaction in prostate cancer — the topic of this entry.
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