Game theoretic analysis of motility in cancer metastasis

As I am starting to write this post, the last of the 4th of July fireworks are winding down outside. I am currently traveling through New York on my way to Swarmfest 2013 in Orlando, FL and to visit David Basanta and Jacob Scott at the Integrated Mathematical Oncology Department of Moffitt Cancer Research Institute in Tampa, FL. The weather is unbearably hot already, so I imagine I will struggle in Florida, especially since I forgot all my shorts in Montreal!

MetastasisThe more important struggle, however, will be my lack of background in biology and medicine. On Jake’s suggestion, I decided to look at a paper of David’s on an evolutionary game theoretic approach to the emergence of motility in cancer cells. As far as I understand, one of the key steps in going from a benign tumor to a malignant cancer is metastasis or the ability of a cancer to spread from one organ to another non-adjacent organ. To achieve this, a cancer cell has to transition from a simple proliferative cell to a motile one. However, motility usually involves a cost to the organism.
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