## Edge effects on the invasiveness of solid tumours

July 29, 2013 12 Comments

Careful readers might have noticed that, until last night’s post, the blog was silent for an atypically long 10 days (17 days since I last posted). As usual, the primary culprit is laziness, but this time it is not alone! After my fun visit to the Integrated Mathematical Oncology Department of the Moffit Cancer Research Center, I have been working closely with Jacob Scott and David Basanta to finish up our first joint paper. The last week was particularly busy as we pushed the paper out for submission and posted a draft to the ArXiv.

We look at the effect of spatial structure, in particular a spatial boundary, on the evolutionary dynamics of motility in cancer. For a tumor, one of the key steps in going from a benign to malignant is gaining the ability to spread from one organ to another non-adjacent organ. To achieve this, a cancer cell has to transition from simple proliferative cells (AG) to a motile ones (INV). However, motility usually involves a cost to the organism. We show that spatial structure can lower this cost, and smaller neighborhood size at an edge can promote motile cells at the boundary even when they are absent in the tumour body.

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## Hunger Games themed semi-iterated prisoner’s dilemma tournament

July 28, 2013 by Artem Kaznatcheev 12 Comments

With all the talk surrounding it, crowdsourcing science might seem like a new concept and it might be true for citizen science efforts, but it is definitely an old trick to source your research to other researchers. In fact, evolutionary game theory was born (or at least popularized) by one such crowdsourcing exercise; in 1980, Robert Axelrod wanted to find out the best strategy for iterated prisoner’s dilemma and reached out to prominent researchers for strategy submissions to a round-robin tournmanet. Tit-for-tat was the winning strategy, but the real victor was Axelrod. His 1981 paper with Hamilton analyzing the result went on to become a standard reference in applications of game theory to social questions (at least outside of economics), agent-based modeling, and — of course — evolutionary game theory. Of Axelrod’s sizeable 47,222 (at time of writing) citations, almost half (23,370) come from this single paper. The tradition of tournaments continues among researchers, I’ve even discussed an imitation tournament on imitation previously.

The cynical moral of the tale: if you want to be noticed then run a game theory tournament. The folks at Brilliant.org — a website offering weekly olympiad-style challange problems in math and physics — took this message to heart, coupled it to the tried-and-true marketing technique of linking to a popular movie/book franchise, and decided to run a Hunger Games themed semi-iterated Prisoner’s dillema tournament. Submit a quick explanation of your strategy and Python script to play the game, and you could be one of the 5 winners of the $1,000 grand prize. Hooray! The submission deadline is August 18th, 2013 and all you need is a Brilliant account and it seems that these are free. If you are a reader of TheEGG blog then I recommend submitting a strategy, and discussing it in the comments (either before or after the deadline); I am interested to see what you come up with.

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Filed under Commentary, Meta, Models, Simulation Tagged with current events, prisoner's dilemma, public good, Robert Axelrod